Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies
Identifieur interne : 000222 ( an2020/Analysis ); précédent : 000221; suivant : 000223Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies
Auteurs : Philip F. Uzor [Nigeria]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2020.
Abstract
Malaria is one of the major health problems in developing countries. The disease kills a large number of people every year and also affects financial status of many countries. Resistance of the plasmodium parasite, the causative agent, to the existing drugs, including chloroquine, mefloquine, and artemisinin based combination therapy (ACT), is a serious global issue in malaria treatment and control. This warrants an urgent quest for novel compounds, particularly from natural sources such as medicinal plants. Alkaloids have over the years been recognized as important phytoconstituents with interesting biological properties. In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented. Several classes of alkaloids, including terpenoidal, indole, bisindole, quinolone, and isoquinoline alkaloids, were identified with a promising antimalarial activity. It is hoped that the reports of the review work will spur further research into the structural modification and/or development of the interesting compounds as novel antimalarial drugs.
Url:
DOI: 10.1155/2020/8749083
PubMed: 32104196
PubMed Central: 7037883
Affiliations:
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Uzor</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, 410001 Nsukka, Enugu State, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, 410001 Nsukka, Enugu State</wicri:regionArea><wicri:noRegion>Enugu State</wicri:noRegion></affiliation></author></analytic><series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title><idno type="ISSN">1741-427X</idno><idno type="eISSN">1741-4288</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Malaria is one of the major health problems in developing countries. The disease kills a large number of people every year and also affects financial status of many countries. Resistance of the plasmodium parasite, the causative agent, to the existing drugs, including chloroquine, mefloquine, and artemisinin based combination therapy (ACT), is a serious global issue in malaria treatment and control. This warrants an urgent quest for novel compounds, particularly from natural sources such as medicinal plants. Alkaloids have over the years been recognized as important phytoconstituents with interesting biological properties. In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented. Several classes of alkaloids, including terpenoidal, indole, bisindole, quinolone, and isoquinoline alkaloids, were identified with a promising antimalarial activity. It is hoped that the reports of the review work will spur further research into the structural modification and/or development of the interesting compounds as novel antimalarial drugs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ashok, P" uniqKey="Ashok P">P. Ashok</name></author><author><name sortKey="Ganguly, S" uniqKey="Ganguly S">S. Ganguly</name></author><author><name sortKey="Murugesan, S" uniqKey="Murugesan S">S. Murugesan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaur, K" uniqKey="Kaur K">K. Kaur</name></author><author><name sortKey="Jain, M" uniqKey="Jain M">M. Jain</name></author><author><name sortKey="Khan, S I" uniqKey="Khan S">S. I. Khan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schlitzer, M" uniqKey="Schlitzer M">M. 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Carroll</name></author><author><name sortKey="Davis, R A" uniqKey="Davis R">R. A. Davis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rasamison, V E" uniqKey="Rasamison V">V. E. Rasamison</name></author><author><name sortKey="Brodie, P J" uniqKey="Brodie P">P. J. Brodie</name></author><author><name sortKey="Merino, E F" uniqKey="Merino E">E. F. Merino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levrier, C" uniqKey="Levrier C">C. Levrier</name></author><author><name sortKey="Balastrier, M" uniqKey="Balastrier M">M. Balastrier</name></author><author><name sortKey="Beattie, K D" uniqKey="Beattie K">K. D. Beattie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C. Wang</name></author><author><name sortKey="Wan, J" uniqKey="Wan J">J. Wan</name></author><author><name sortKey="Mei, Z" uniqKey="Mei Z">Z. Mei</name></author><author><name sortKey="Xang, X" uniqKey="Xang X">X. Xang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teng, W C" uniqKey="Teng W">W.-C. Teng</name></author><author><name sortKey="Chan, W" uniqKey="Chan W">W. Chan</name></author><author><name sortKey="Suwanarusk, R" uniqKey="Suwanarusk R">R. Suwanarusk</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Nigeria</li></country></list><tree><country name="Nigeria"><noRegion><name sortKey="Uzor, Philip F" sort="Uzor, Philip F" uniqKey="Uzor P" first="Philip F." last="Uzor">Philip F. Uzor</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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